Protein Name:
Neurochondrin
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UniprotKB/SwissProt ID: Q9UBB6 (Q9UBB6)
Gene Name:
NCDN
Organism: Homo sapiens (Human)
Function: Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Endosome membrane. Cell projection, dendrite. Postsynapse
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9UBB6
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
351 |
MELGIQECTR C EQSLLKEPQK |
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| 2 |
415 |
EETSSLRKEV C QLLPFLVRYA |
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37478858
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| 3 |
469 |
DALRLLLPGW C HLTVEDGPRE |
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| 4 |
725 |
SHYRMAALEQ C LSEP------ |
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| 5 |
98 |
LLTTKEAPDG C PDHVLRALGV |
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