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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Bifunctional L-3-cyanoalanine synthase/cysteine synthase C1, mitochondrial

UniprotKB/SwissProt ID: Q9S757 (Q9S757)

Gene Name: CYSC1

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Acts as a major beta-cyanoalanine synthase. The cyanoalanine synthesis reaction is more efficient than the cysteine synthase activity. Probably unable to interact with SAT and to form the decameric Cys synthase complex (CSC) and is therefore not an enzymatically true OASTL protein. Probably involved in the detoxification of cyanide that arises from ethylene biosynthesis. Maintains a low level of cyanide for proper root hair development

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR005856 Cys_synth
IPR050214 Cys_Synth/Cystath_Beta-Synth
IPR005859 CysK
IPR001216 P-phosphate_BS
IPR001926 TrpB-like_PALP
IPR036052 TrpB-like_PALP_sf

The S-nitrosylation sites of Q9S757

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 72 LVFLNKVTEG C EAYVAAKQEH  CCCHHHHHHH H CCCCCCHHHH  22115780
2 87 AAKQEHFQPT C SIKDRPAIAM  CCCHHHHHHH H CCCCCCHHHH