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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: CCN family member 2

UniprotKB/SwissProt ID: Q9R1E9 (Q9R1E9)

Gene Name: Ccn2

Organism: Rattus norvegicus (Rat)

Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted, extracellular space, extracellular matrix. Secreted

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR050941 CCN
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR043973 TSP1_CCN
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom

The S-nitrosylation sites of Q9R1E9

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 118 YRSGESFQSS C KYQCTCLDGA   
2 226 STRVTNDNTF C RLEKQSRLCM