UniprotKB/SwissProt ID: Q9R0X5 (Q9R0X5)
Gene Name:
Rpgr
Organism: Mus musculus (Mouse)
Function: Acts as a guanine-nucleotide releasing factor (GEF) for RAB8A and RAB37 by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:38536817). GEF activity towards RAB8A may facilitate ciliary trafficking by modulating ciliary intracellular localization of RAB8A (By similarity). GEF activity towards RAB37 maintains autophagic homeostasis and retinal function (PubMed:38536817). Involved in photoreceptor integrity (PubMed:22563472, PubMed:38536817). May control cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia (By similarity) Isoform 5 may play a critical role in spermatogenesis and in intraflagellar transport processes
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme
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