UniprotKB/SwissProt ID: Q9R0N3 (Q9R0N3)
Gene Name:
Syt11
Organism: Mus musculus (Mouse)
Function: Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+) (Probable). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval (PubMed:29311685). Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process (PubMed:29311685). Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity (PubMed:30808661). In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis (PubMed:23303671, PubMed:28686317). In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (PubMed:26450452). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasmic vesicle membrane. Perikaryon. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane. Lysosome membrane. Cytoplasmic vesicle, phagosome. Cell projection, axon. Cell projection, dendrite. Postsynaptic density. Recycling endosome membrane. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Perikaryon
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