Protein Name:
Plasma membrane calcium-transporting ATPase 2
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UniprotKB/SwissProt ID: Q9R0K7 (Q9R0K7)
Gene Name:
Atp2b2
Organism: Mus musculus (Mouse)
Function: ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:9668038). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics (PubMed:17409239, PubMed:20083513). At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (PubMed:17409239, PubMed:20083513). Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (By similarity) (PubMed:9668038). Regulates Ca(2+) signaling through dissipation of Ca(2+) transients generated by store-operated channels (By similarity). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (PubMed:15302868)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Apical cell membrane. Basolateral cell membrane. Synapse
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9R0K7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
442 |
DNNLVRHLDA C ETMGNATAIC |
CCCCCHHHHH C CCCCCCCCCC |
4.46% |
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| 2 |
452 |
CETMGNATAI C SDKTGTLTTN |
CCCCCHHHHH C CCCCCCCCCC |
3.9% |
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| 3 |
526 |
LPRQVGNKTE C GLLGFVLDLR |
CCCCCHHHHH C CCCCCCCCCC |
5.87% |
22588120
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| 4 |
621 |
MVKKVIEPMA C DGLRTICVAY |
CCCCCHHHHH C CCCCCCCCCC |
3.29% |
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| 5 |
628 |
PMACDGLRTI C VAYRDFPSSP |
CCCCCHHHHH C CCCCCCCCCC |
1.1% |
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