Protein Name:
Peroxisomal acyl-coenzyme A oxidase 1
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UniprotKB/SwissProt ID: Q9R0H0 (Q9R0H0)
Gene Name:
Acox1
Organism: Mus musculus (Mouse)
Function: Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)) Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro Is active against a much broader range of substrates and shows activity towards long-chain acyl-CoAs
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Peroxisome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9R0H0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
199 |
VLAQLITRGE C YGLHAFVVPI |
CCHHHHHHHH H HHCCHHHHHH |
3.48% |
21278135
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| 2 |
392 |
TWTANAGIEE C RMACGGHGYS |
CCHHHHHHHH H HHCCHHHHHH |
2.03% |
21278135
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| 3 |
531 |
VDLVRASEAH C HYVTVKVFAD |
CCHHHHHHHH H HHCCHHHHHH |
2.97% |
21278135
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| 4 |
559 |
RAVQAVLRNL C LLYSLYGISQ |
CCHHHHHHHH H HHCCHHHHHH |
2.55% |
21278135
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