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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: 17-beta-hydroxysteroid dehydrogenase type 6

UniprotKB/SwissProt ID: Q9R092 (Q9R092)

Gene Name: Hsd17b6

Organism: Mus musculus (Mouse)

Function: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Microsome membrane. Early endosome membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam

The S-nitrosylation sites of Q9R092

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 60 DRRGMRVLAA C LTEKGAEELR