UniprotKB/SwissProt ID: Q9QZW0 (Q9QZW0)
Gene Name:
Atp11c
Organism: Mus musculus (Mouse)
Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:24898253, PubMed:24904167, PubMed:26799398, PubMed:30018401). Major PS-flippase in immune cell subsets (PubMed:30018401). In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages (PubMed:24898253). Required for B cell differentiation past the pro-B cell stage (PubMed:21423173). Seems to mediate PS flipping in pro-B cells (PubMed:21423172, PubMed:26799398). May be involved in the transport of cholestatic bile acids (PubMed:21518881)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Endoplasmic reticulum membrane. Early endosome membrane. Recycling endosome membrane
|
|
|
