UniprotKB/SwissProt ID: Q9QZS3 (Q9QZS3)
Gene Name:
Numb
Organism: Mus musculus (Mouse)
Function: Regulates clathrin-mediated receptor endocytosis (By similarity). Plays a role in the process of neurogenesis (PubMed:10841580, PubMed:12410312, PubMed:15273690, PubMed:17174898). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (PubMed:12410312, PubMed:15273690). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis (PubMed:12410312, PubMed:15273690). Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (PubMed:17174898). May also mediate local repair of brain ventricular wall damage (PubMed:17174898)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Endosome membrane
|
|
|
