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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Afadin

UniprotKB/SwissProt ID: Q9QZQ1 (Q9QZQ1)

Gene Name: Afdn

Organism: Mus musculus (Mouse)

Function: Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (By similarity). May play a key role in the organization of epithelial structures of the embryonic ectoderm (PubMed:10477764). Essential for the organization of adherens junctions (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell junction, adherens junction

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR028842 Afadin
IPR037977 CBD_Afadin
IPR002710 Dilute_dom
IPR000253 FHA_dom
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000159 RA_dom
IPR008984 SMAD_FHA_dom_sf
IPR029071 Ubiquitin-like_domsf

The S-nitrosylation sites of Q9QZQ1

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1700 YEPPSLSSAP C APPPPPQRNA