UniprotKB/SwissProt ID: Q9QZI9 (Q9QZI9)
Gene Name:
Serinc3
Organism: Mus musculus (Mouse)
Function: Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in gammaretroviral surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to loss of infectivity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Golgi apparatus membrane
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