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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Mitochondrial dicarboxylate carrier

UniprotKB/SwissProt ID: Q9QZD8 (Q9QZD8)

Gene Name: Slc25a10

Organism: Mus musculus (Mouse)

Function: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane (PubMed:33746082). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes (PubMed:16027120, PubMed:30943427, PubMed:33746082). Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (PubMed:33746082)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion inner membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR002067 Mit_carrier
IPR050391 Mito_Metabolite_Transporter
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf

The S-nitrosylation sites of Q9QZD8

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 180 GALVTVGQLS C YDQAKQLVLS   
2 239 SKGEYQGVFH C AMETAKLGPQ