Protein Name:
DCN1-like protein 1
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UniprotKB/SwissProt ID: Q9QZ73 (Q9QZ73)
Gene Name:
Dcun1d1
Organism: Mus musculus (Mouse)
Function: Part of an E3 ubiquitin ligase complex for neddylation (By similarity). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:26792857). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (By similarity). Also acts as an oncogene facilitating malignant transformation and carcinogenic progression (PubMed:20563250)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9QZ73
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
29 |
TQSSEKTAVS C LSQNDWKLDV |
CCCCCHHHHH H HHHEEEEECC |
3.22% |
21278135
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