Protein Name:
Interleukin-36 receptor antagonist protein
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UniprotKB/SwissProt ID: Q9QYY1 (Q9QYY1)
Gene Name:
Il36rn
Organism: Mus musculus (Mouse)
Function: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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