UniprotKB/SwissProt ID: Q9QY42 (Q9QY42)
Gene Name:
Gpr37
Organism: Mus musculus (Mouse)
Function: G-protein-coupled receptor that plays a role in several physiological pathways such as resolution of inflammatory pain and oligodendrocyte differentiation (PubMed:26961174, PubMed:28642167, PubMed:30010619). Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity). Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination (PubMed:34678058). Mechanistically, plays a negative role in oligodendrocyte differentiation and myelination during development via activation of the ERK1/2 signaling pathway (PubMed:26961174). Therefore, regulates the stability of myelin or resistance of myelin itself to demyelination (PubMed:28642167). Upon activation by neuroprotectin D1 (NPD1), promotes the activation of phagocytosis in macrophages as well as the shift in cytokine release toward an anti-inflammatory profile, and thus helps to reverse inflammatory pain (PubMed:30010619). In addition, the increased macrophage phagocytosis mediates protection against sepsis upon pathogen infection (PubMed:33731716). Additionally, extracellular vesicles derived from efferocyte express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor TIM4 via an ERK-AP1-dependent signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation (PubMed:37436891). May also act as a maturation factor of LRP6, protecting LRP6 from the endoplasmic reticulum (ER)-associated protein degradation (ERAD) and thereby promoting the Wnt/beta-catenin signaling pathway (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, dendrite. Synapse. Cell membrane. Endoplasmic reticulum membrane
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