UniprotKB/SwissProt ID: Q9QXP6 (Q9QXP6)
Gene Name:
Mkrn1
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase (By similarity). Has negative and positive effects on RNA polymerase II-dependent transcription
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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