UniprotKB/SwissProt ID: Q9QUN9 (Q9QUN9)
Gene Name:
Dkk3
Organism: Mus musculus (Mouse)
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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