Protein Name:
Rabankyrin-5
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UniprotKB/SwissProt ID: Q9P2R3 (Q9P2R3)
Gene Name:
ANKFY1
Organism: Homo sapiens (Human)
Function: Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Endosome membrane. Early endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9P2R3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
460 |
TDAPDTATGN C LLQRAAGAGN |
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| 2 |
675 |
NQLPLVVDAI C TRGADMSVPD |
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