Protein Name:
Leucine--tRNA ligase, cytoplasmic
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UniprotKB/SwissProt ID: Q9P2J5 (Q9P2J5)
Gene Name:
LARS1
Organism: Homo sapiens (Human)
Function: Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) (PubMed:25051973, PubMed:32232361). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA (PubMed:25051973). To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) (PubMed:25051973)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9P2J5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1053 |
EAEDKIREDC C PGKPLNVFRI |
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| 2 |
1093 |
TKIEIRQGDN C DSIIRRLMKM |
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| 3 |
113 |
KLKREIELYG C PPDFPDEEEE |
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| 4 |
248 |
TIYSPKDGQP C MDHDRQTGEG |
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| 5 |
326 |
FETVNGDIFI C TQKAARNMSY |
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| 6 |
446 |
GFGNLSAVTI C DELKIQSQND |
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| 7 |
522 |
KQVMSRSSDE C VVALCDQWYL |
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| 8 |
546 |
EENWKKQTSQ C LKNLETFCEE |
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| 9 |
554 |
SQCLKNLETF C EETRRNFEAT |
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| 10 |
573 |
ATLGWLQEHA C SRTYGLGTHL |
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| 11 |
70 |
HLGHTFSLSK C EFAVGYQRLK |
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