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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: HEAT repeat-containing protein 5B

UniprotKB/SwissProt ID: Q9P2D3 (Q9P2D3)

Gene Name: HEATR5B

Organism: Homo sapiens (Human)

Function: Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR040108 Laa1/Sip1/HEATR5
IPR046837 Laa1/Sip1/HEATR5-like_HEAT

The S-nitrosylation sites of Q9P2D3

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1693 LNEDDMEKEA C TVLGEGGDSG