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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: DNA-directed RNA polymerase I subunit RPA12

UniprotKB/SwissProt ID: Q9P1U0 (Q9P1U0)

Gene Name: POLR1H

Organism: Homo sapiens (Human)

Function: Core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol I active site to monitor transcription fidelity and cleave mis-incorporated 5'-ribonucleotides

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleolus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR019761 DNA-dir_RNA_pol-M_15_CS
IPR012164 Rpa12/Rpb9/Rpc10/TFS
IPR034004 Zn_ribbon_RPA12_C
IPR001222 Znf_TFIIS

The S-nitrosylation sites of Q9P1U0

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 115 ADEGQTVFYT C TNCKFQEKED   
2 118 GQTVFYTCTN C KFQEKEDS--   
3 78 MPMSVEEGPE C QGPVVDRRCP