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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Vacuolar protein sorting-associated protein 54

UniprotKB/SwissProt ID: Q9P1Q0 (Q9P1Q0)

Gene Name: VPS54

Organism: Homo sapiens (Human)

Function: Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Golgi apparatus, trans-Golgi network. Membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR039745 Vps54
IPR012501 Vps54_C
IPR019515 VPS54_N

The S-nitrosylation sites of Q9P1Q0

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 344 HSFRHLGSQL C ELEKLIDKMM