Protein Name:
Vesicle-associated membrane protein-associated protein A
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UniprotKB/SwissProt ID: Q9P0L0 (Q9P0L0)
Gene Name:
VAPA
Organism: Homo sapiens (Human)
Function: Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Cell membrane. Cell junction, tight junction. Nucleus membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9P0L0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
128 |
PDELMDSKLR C VFEMPNENDK |
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| 2 |
179 |
DTETRKLMEE C KRLQGEMMKL |
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