Protein Name:
Splicing factor C9orf78
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UniprotKB/SwissProt ID: Q9NZ63 (Q9NZ63)
Gene Name:
C9orf78
Organism: Homo sapiens (Human)
Function: Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome, centromere
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9NZ63
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
145 |
QKVKPKNAED C LYELPENIRV |
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