Protein Name:
tRNA (guanine(26)-N(2))-dimethyltransferase
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UniprotKB/SwissProt ID: Q9NXH9 (Q9NXH9)
Gene Name:
TRMT1
Organism: Homo sapiens (Human)
Function: Dimethylates a single guanine residue at position 26 of most nuclear- and mitochondrial-encoded tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:10982862, PubMed:28784718, PubMed:37204604, PubMed:39786990). tRNA guanine(26)-dimethylation is required for redox homeostasis and ensure proper cellular proliferation and oxidative stress survival (PubMed:28784718)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9NXH9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
150 |
QPRTAAVGEI C EEGLHVLEGL |
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| 2 |
376 |
PSGRAKFSAA C GPPVTPECEH |
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| 3 |
639 |
PRVSADAAPD C PETSNQTPPG |
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