Protein Name:
Sphingomyelin phosphodiesterase 4
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UniprotKB/SwissProt ID: Q9NXE4 (Q9NXE4)
Gene Name:
SMPD4
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function (PubMed:31495489). May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924). In skeletal muscle, mediates TNF-stimulated oxidant production (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Golgi apparatus membrane. Nucleus envelope. Cell membrane, sarcolemma
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR024129
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Sphingomy_SMPD4 |
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The S-nitrosylation sites of Q9NXE4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
164 |
PGPVKASIQE C ILPDSPLYHN |
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