Protein Name:
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
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UniprotKB/SwissProt ID: Q9NX74 (Q9NX74)
Gene Name:
DUS2
Organism: Homo sapiens (Human)
Function: Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704, PubMed:34798057, PubMed:38680565). Specifically modifies U20 in cytoplasmic tRNAs (PubMed:38680565). Activity depends on the presence of guanosine at position 19 in the tRNA substrate (PubMed:38680565). Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Endoplasmic reticulum
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9NX74
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
116 |
DVAGIDVNMG C PKQYSTKGGM |
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