Protein Name:
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
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UniprotKB/SwissProt ID: Q9NWQ8 (Q9NWQ8)
Gene Name:
PAG1
Organism: Homo sapiens (Human)
Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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