Protein Name:
ATP-dependent RNA helicase DDX18
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UniprotKB/SwissProt ID: Q9NVP1 (Q9NVP1)
Gene Name:
DDX18
Organism: Homo sapiens (Human)
Function: ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop (PubMed:35858569). Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus. Chromosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9NVP1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
329 |
TPGFMYKNLQ C LVIDEADRIL |
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| 2 |
407 |
VDGLEQGYVV C PSEKRFLLLF |
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| 3 |
481 |
FCNADSGTLL C TDVAARGLDI |
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