Protein Name:
Fanconi anemia group I protein
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UniprotKB/SwissProt ID: Q9NVI1 (Q9NVI1)
Gene Name:
FANCI
Organism: Homo sapiens (Human)
Function: Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9NVI1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1085 |
VNLRTAAPTV C LLVLSQAEKV |
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| 2 |
1184 |
TALVRYYLQV C QSSGGIPKNM |
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| 3 |
650 |
DLLPPLKLEA C ILTQGDKISL |
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| 4 |
875 |
QNPEKIFQNL C DITRVLLWRY |
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