Protein Name:
4'-phosphopantetheine phosphatase
|
UniprotKB/SwissProt ID: Q9NVE7 (Q9NVE7)
Gene Name:
PANK4
Organism: Homo sapiens (Human)
Function: Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068). May play a role in the physiological regulation of CoA intracellular levels (Probable)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q9NVE7
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
155 |
EDVMTCLIKG C NFVLKNIPHE |
|
|
|
| 2 |
451 |
DALARKYWLT C FEEALDGVVK |
|
|
|
| 3 |
513 |
VRSLLDTREH C LNEFNFPDPY |
|
|
|
| 4 |
537 |
KQRENGVALR C FPGVVRSLDA |
|
|
|
| 5 |
699 |
LLVQTGSSSP C LDLSRLDKGL |
|
|
|
|
