Protein Name:
Midasin
|
UniprotKB/SwissProt ID: Q9NU22 (Q9NU22)
Gene Name:
MDN1
Organism: Homo sapiens (Human)
Function: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q9NU22
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1394 |
EPVLLVGDTG C GKTTICQVFA |
|
|
|
| 2 |
1867 |
VQHEKTKIFG C QNPFRQGGGR |
|
|
|
| 3 |
2158 |
SHFLLTYKPK C LGEGGKAITM |
|
|
|
| 4 |
3070 |
NLNRPIFSKC C FEVLTSSWRA |
|
|
|
| 5 |
3263 |
YVKEELHQLQ C EWKTRNLSSQ |
|
|
|
| 6 |
3985 |
KKFEAVLSEP C RSSLVESDKE |
|
|
|
| 7 |
4192 |
LTEISSSWDG C QKYFYRSLAR |
|
|
|
| 8 |
4371 |
PIPGSQLPSG C RMRKQDHLWQ |
|
|
|
| 9 |
4517 |
QMEIAIRAIL C AIQNLEERKN |
|
|
|
| 10 |
554 |
ELSLRDLLNW C NRIAHSFDSS |
|
|
|
| 11 |
979 |
RALRFAASNP C GNIQRSLYEG |
|
|
|
|
