Protein Name:
FIGNL1-interacting regulator of recombination and mitosis
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UniprotKB/SwissProt ID: Q9NSG2 (Q9NSG2)
Gene Name:
FIRRM
Organism: Homo sapiens (Human)
Function: Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities (PubMed:34260926). Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis (PubMed:34260926). In complex with FIGL1 may regulate homologous recombination (PubMed:29608566)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Chromosome, centromere, kinetochore. Nucleus. Chromosome, centromere. Midbody. Cytoplasm, cytoskeleton, spindle
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9NSG2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
365 |
SQPKEVQTLW C TDSQVSETTT |
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