Protein Name:
PRKCA-binding protein
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UniprotKB/SwissProt ID: Q9NRD5 (Q9NRD5)
Gene Name:
PICK1
Organism: Homo sapiens (Human)
Function: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, perinuclear region. Membrane. Membrane. Postsynaptic density. Synapse, synaptosome. Cytoplasm, cytoskeleton
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9NRD5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
413 |
AGPLDKGGSW C DS-------- |
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