Protein Name:
Gephyrin
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UniprotKB/SwissProt ID: Q9NQX3 (Q9NQX3)
Gene Name:
GPHN
Organism: Homo sapiens (Human)
Function: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940) Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Postsynaptic cell membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, dendrite. Postsynaptic density
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9NQX3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
154 |
LPGSKKGSQE C FQFILPALPH |
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37478858
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| 2 |
293 |
SCPTPKVQSR C SSKENILRAS |
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37478858
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| 3 |
419 |
MRVTTGAPIP C GADAVVQVED |
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