Protein Name:
Xaa-Pro aminopeptidase 3
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UniprotKB/SwissProt ID: Q9NQH7 (Q9NQH7)
Gene Name:
XPNPEP3
Organism: Homo sapiens (Human)
Function: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala (PubMed:25609706, PubMed:28476889). Also shows low activity towards peptides with Ala or Ser at the P1 position (PubMed:28476889) Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Cytoplasm. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9NQH7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
290 |
AFLYAKFEFE C RARGADILAY |
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| 2 |
334 |
DGEMVLLDGG C ESSCYVSDIT |
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| 3 |
492 |
QDSPLILSAD C PKEMNDIEQI |
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| 4 |
503 |
PKEMNDIEQI C SQAS------ |
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