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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Serine protease inhibitor Kazal-type 5

UniprotKB/SwissProt ID: Q9NQ38 (Q9NQ38)

Gene Name: SPINK5

Organism: Homo sapiens (Human)

Function: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR050159 Kazal-type_SerProtInhib
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf

The S-nitrosylation sites of Q9NQ38

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 496 KAKREAAKEI C SEFRDQVRNG