Protein Name:
Chaperone Ric-8A
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UniprotKB/SwissProt ID: Q9NPQ8 (Q9NPQ8)
Gene Name:
RIC8A
Organism: Homo sapiens (Human)
Function: Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (PubMed:16629901)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cell cortex. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9NPQ8
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
258 |
YRHLGTLLRH C VMIATAGDRT |
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| 2 |
341 |
VAPVLSVLTE C ARMHRPARKF |
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| 3 |
79 |
SVRILSRDRN C LDPFTSRQSL |
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