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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Inositol-3-phosphate synthase 1

UniprotKB/SwissProt ID: Q9NPH2 (Q9NPH2)

Gene Name: ISYNA1

Organism: Homo sapiens (Human)

Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:15024000, PubMed:23902760). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (PubMed:15024000)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR002587 Myo-inos-1-P_Synthase
IPR013021 Myo-inos-1-P_Synthase_GAPDH
IPR036291 NAD(P)-bd_dom_sf

The S-nitrosylation sites of Q9NPH2

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 235 VLWTANTERF C EVIPGLNDTA   
2 380 LYTPGEEPDH C VVIKYVPYVG   
3 485 VVNALFRQRS C IENILRACVG   
4 541 KGPVPAATNG C TGDANGHLQE