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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: 110 kDa U5 small nuclear ribonucleoprotein component CLO

UniprotKB/SwissProt ID: Q9LNC5 (Q9LNC5)

Gene Name: CLO

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Splicing factor involved in pre-mRNA splicing and component of the spliceosome (PubMed:18702672, PubMed:19168457). Essential for reproduction. In female gametophyte, is necessary for the egg cell and central cell fate determination and hence reproductive success. Involved in a mechanism that prevents accessory cells from adopting gametic cell fate. Is necessary to restrict LIS expression to interfere with egg-cell specification (PubMed:18702672). Probable component of U5 small nuclear ribonucleoprotein (snRNP) that is required for pre-mRNA splicing. Plays an essential role in female gametogenesis and embryo development (PubMed:19261069). Required for the control of polarized cell growth and cell proliferation during floral organ morphogenesis (PubMed:19168457)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus speckle

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR035647 EFG_III/V
IPR000640 EFG_V-like
IPR004161 EFTu-like_2
IPR031950 EFTUD2_N
IPR027417 P-loop_NTPase
IPR020568 Ribosomal_Su5_D2-typ_SF
IPR014721 Ribsml_uS5_D2-typ_fold_subgr
IPR005225 Small_GTP-bd
IPR044121 Snu114_GTP-bd
IPR000795 T_Tr_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR005517 Transl_elong_EFG/EF2_IV
IPR035655 U5-116kDa_C

The S-nitrosylation sites of Q9LNC5

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 211 LEDSRSKSYL C NIMDTPGHVN   
2 677 VKVADPVVSF C ETVVESSSMK