Protein Name:
BAG family molecular chaperone regulator 3
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UniprotKB/SwissProt ID: Q9JLV1 (Q9JLV1)
Gene Name:
Bag3
Organism: Mus musculus (Mouse)
Function: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9JLV1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
154 |
MTEAAQTDKQ C GQMPATATTA |
CCCCCCCCCH H CCCCCCCCCC |
5.14% |
21278135
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| 2 |
185 |
ERSQSPAASD C SSSSSSASLP |
CCCCCCCCCH H CCCCCCCCCC |
3.83% |
21278135
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| 3 |
378 |
EVKVSSAPIP C PSPSPAPSAV |
CCCCCCCCCH H CCCCCCCCCC |
5.58% |
21278135
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