Protein Name:
Proteasomal ubiquitin receptor ADRM1
|
UniprotKB/SwissProt ID: Q9JKV1 (Q9JKV1)
Gene Name:
Adrm1
Organism: Mus musculus (Mouse)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:18497827). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:18497827). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:18497827). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497827). Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (By similarity). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q9JKV1
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
88 |
DDCEFKRVPQ C PSGRVYVLKF |
CCCCCCCCCC C CCCCCCCCCE |
2.07% |
21278135
|
|
