UniprotKB/SwissProt ID: Q9JKF6 (Q9JKF6)
Gene Name:
Nectin1
Organism: Mus musculus (Mouse)
Function: Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system (PubMed:11827984, PubMed:15328010, PubMed:18703497, PubMed:21798896, PubMed:22955284). Acts by forming homophilic or heterophilic trans-dimers (PubMed:11827984). Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4 (PubMed:11827984, PubMed:21798896). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (PubMed:15328010). Involved in synaptogegesis (PubMed:11827984). Has some neurite outgrowth-promoting activity (PubMed:22955284). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (PubMed:21798896). Required for enamel mineralization (PubMed:18703497) (Microbial infection) Acts as a receptor for pseudorabies virus/PRV
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell junction, adherens junction. Presynaptic cell membrane
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