Protein Name:
Ras GTPase-activating-like protein IQGAP1
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UniprotKB/SwissProt ID: Q9JKF1 (Q9JKF1)
Gene Name:
Iqgap1
Organism: Mus musculus (Mouse)
Function: Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (PubMed:20951348). Binds to activated CDC42 but does not stimulate its GTPase activity (PubMed:16968698). Associates with calmodulin. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Nucleus. Cytoplasm. Cytoplasm, cell cortex. Apical cell membrane. Basolateral cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9JKF1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1534 |
VDYYKSYIKT C LDNLASKGKV |
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