UniprotKB/SwissProt ID: Q9JJ28 (Q9JJ28)
Gene Name:
Flii
Organism: Mus musculus (Mouse)
Function: Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (PubMed:22581781, PubMed:37126682). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By similarity). Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (PubMed:11971982, PubMed:21430700, PubMed:22581781). May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, focal adhesion. Cell projection, podosome
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