Protein Name:
Phospholipid scramblase 1
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UniprotKB/SwissProt ID: Q9JJ00 (Q9JJ00)
Gene Name:
Plscr1
Organism: Mus musculus (Mouse)
Function: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific distribution of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:32110987). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (PubMed:32110987). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (By similarity). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724). May contribute to cytokine-regulated cell proliferation and differentiation (PubMed:12010804)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region
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Graphical Visualization of S-nitrosylation Sites:
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