Protein Name:
Phospholipid scramblase 3
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UniprotKB/SwissProt ID: Q9JIZ9 (Q9JIZ9)
Gene Name:
Plscr3
Organism: Mus musculus (Mouse)
Function: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (By similarity). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (By similarity). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (Probable). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (By similarity). Regulates cardiolipin de novo biosynthesis and its resynthesis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion membrane. Mitochondrion inner membrane. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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