Protein Name:
Synaptic vesicle glycoprotein 2A
|
UniprotKB/SwissProt ID: Q9JIS5 (Q9JIS5)
Gene Name:
Sv2a
Organism: Mus musculus (Mouse)
Function: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 (PubMed:16543415) (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E (PubMed:21483489) (Microbial infection) Receptor for C.botulinum neurotoxin type E (BoNT/E); the toxin probably binds via extracellular loop 4 (PubMed:18815274). It probably requires glycosylation of Asn-573 (PubMed:18815274)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Presynapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q9JIS5
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
198 |
FVLPSAEKDM C LSDSNKGMLG |
CCCCHHHHHH H HHCHHHHHHH |
4.76% |
24895380
|
|
