Protein Name:
Pannexin-1
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UniprotKB/SwissProt ID: Q9JIP4 (Q9JIP4)
Gene Name:
Panx1
Organism: Mus musculus (Mouse)
Function: Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed:30814251). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (PubMed:22311122). Can release ATP upon activation through phosphorylation or cleavage at C-terminus (PubMed:32238926). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity) During apoptosis and after cleavage by caspases of the C-terminal tail, acts as a plasma membrane channel which mediates the regulated release of find-me signals, such as nucleotides ATP and UTP, and selective plasme membrane permeability
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9JIP4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
346 |
ENISELKSYK C LKVLENIKSN |
CCHHHHHHHH H HHHHHCCCCC |
3.18% |
23033481
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| 2 |
40 |
LELAVDKMVT C IAVGLPLLLI |
CCHHHHHHHH H HHHHHCCCCC |
0.97% |
23033481
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